基于多角度光学投影表面重建的三维自发荧光光源定位算法

宁楠楠; 刘侠; 邓可欣; 吴萍; 王坤; 田捷

doi:10.3724/SP.J.1004.2014.01793

基于多角度光学投影表面重建的三维自发荧光光源定位算法

doi: 10.3724/SP.J.1004.2014.01793

宁楠楠¹,
刘侠^1, ,,
邓可欣³,
吴萍²,
王坤²,
田捷^{2 3}

1.
哈尔滨理工大学自动化学院哈尔滨 150080;
2.
中国科学院自动化研究所中国科学院分子影像重点实验室北京 100190;
3.
西安电子科技大学生命科学技术学院西安 710126

基金项目:

国家重点基础研究发展计划（973计划）（2011CB707700），国家自然科学基金项目（61172167），中国科学院科研装备研制项目（YZ201164），黑龙江省自然基金项目（F201311），复杂系统管理与控制国家重点实验室青年基金（Y3S9021F2S）资助

详细信息

作者简介:
宁楠楠哈尔滨理工大学自动化学院硕士研究生. 2009 年获得齐齐哈尔大学计算机与控制工程学院学士学位. 主要研究方向为模式识别与智能系统.E-mail：ningnannan@fingerpass.net.cn

通讯作者:
刘侠哈尔滨理工大学自动化学院教授. 2006 年获得哈尔滨工程大学自动化学院博士学位. 主要研究方向为模式识别与智能系统.E-mail：liuxia@hrbust.edu.cn

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出版历程
- 收稿日期: 2013-08-21
- 修回日期: 2013-12-09
- 刊出日期: 2014-08-20

A 3D Location Method of Bioluminescence Light Source Based on Multi-view Projection Surface Reconstruction

NING Nan-Nan¹,
LIU Xia^{1
, ,},
DENG Ke-Xin³,
WU Ping²,
WANG Kun²,
TIAN Jie^{2 3}

1.
School of Automation, Harbin University of Science and Technology, Harbin 150080;
2.
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190;
3.
School of Life Sciences and Technology, Xidian University, Xi'an 710126

Funds:

Supported by National Basic Research Program of China (973 Program) (2011CB707700), National Natural Science Foundation of China (61172167), Scientific Research and Equipment Development Project of Chinese Academy of Sciences (YZ201164), Natural Science Foundation of Heilongjiang (F201311), Complicated Control and Management System of State Key Laboratory of Youth Fund (Y3S9021F2S)

摘要

摘要: 在自发荧光断层成像（Bioluminescent tomography imaging，BLT）中，双模态融合（光学模态与结构模态）可充分利用结构模态提供的高精度3D几何结构，重建三维表面荧光光通量分布，进而实现小动物内部荧光光源定位.然而，与纯光学模态相比，双模态融合存在采集系统复杂、成本高、数据处理繁琐及存在电离辐射（如CT）等问题.因此，研究基于纯光学3D几何结构的自发荧光光源定位方法对BLT具有重要意义. 本文在搭建纯光学自发荧光断层系统（All-optical bioluminescence tomography system，AOBTS）的基础上，提出一种基于多角度光学投影表面重建的三维自发荧光光源定位方法. 本方法由基于多角度光学投影的3D表面重建、多角度荧光无缝融合、荧光光通量的量化校正以及自发荧光内部光源重建4部分组成. 通过真实小鼠内部植入荧光光源实验表明，与传统纯光学方法相比，本文提出方法不仅改进了3D表面重建方法，而且增加了多角度荧光无缝融合，可实现真实小鼠的三维自发荧光光源定位，初步实验证明具有小动物预临床实验潜力.
- 光学表面重建 /
- 纯光学 /
- 自发荧光重建 /
- 非接触式 /
- 光通量重建
Abstract: In bioluminescent tomography imaging (BLT), dual-modality fusion (optical modality and structural modality) can make full use of high accuracy 3D geometrical structures provided by structural modality reconstruct 3D surface light flux distribution and bioluminescence inner light source reconstruction. However, compared with the all-optical modality, dual-modality fusion has the problems of complicated fusion system, high cost compared with all-optical system, multifarious and exhaustive date processing, and ionizing radiation (for example, CT). Therefore, the 3D location method of bioluminescence light source based on pure optical 3D geometrical structures has significance for BLT. In this paper, we present a 3D location method of bioluminescence light source based on multi-view projection surface reconstruction, and an all-optical bioluminescence tomography system (AOBTS) is developed for this method. The method consists of 3D surface reconstruction based on multi-view optical projection, multi-view luminescent seamless integration, calibration and quantification of the surface light flux and internal bioluminescence reconstruction. An in-vivo BALB/C mouse with an implanted luminescent light source are used to evaluate the performance of the new method. Compared with the conventional optical methods, the new method improves not only the 3D surface reconstruction method but also the multi-view luminescent seamless integration. It has realized 3D real mouse bioluminescence light source localization, and the preliminary test proves its potential application in clinical trial.
- Optical surface reconstruction /
- all-optical /
- bioluminescence tomography reconstruction /
- non-contact /
- light flux reconstruction

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参考文献(34)

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基于多角度光学投影表面重建的三维自发荧光光源定位算法

doi: 10.3724/SP.J.1004.2014.01793

作者简介:
宁楠楠哈尔滨理工大学自动化学院硕士研究生. 2009 年获得齐齐哈尔大学计算机与控制工程学院学士学位. 主要研究方向为模式识别与智能系统.E-mail：ningnannan@fingerpass.net.cn

通讯作者:
刘侠哈尔滨理工大学自动化学院教授. 2006 年获得哈尔滨工程大学自动化学院博士学位. 主要研究方向为模式识别与智能系统.E-mail：liuxia@hrbust.edu.cn

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A 3D Location Method of Bioluminescence Light Source Based on Multi-view Projection Surface Reconstruction

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目录

留言板

基于多角度光学投影表面重建的三维自发荧光光源定位算法

doi: 10.3724/SP.J.1004.2014.01793

作者简介: 宁楠楠 哈尔滨理工大学自动化学院硕士研究生. 2009 年获得齐齐哈尔大学计算机与控制工程学院学士学位. 主要研究方向为模式识别与智能系统.E-mail：ningnannan@fingerpass.net.cn

通讯作者: 刘侠 哈尔滨理工大学自动化学院教授. 2006 年获得哈尔滨工程大学自动化学院博士学位. 主要研究方向为模式识别与智能系统.E-mail：liuxia@hrbust.edu.cn

计量

出版历程

A 3D Location Method of Bioluminescence Light Source Based on Multi-view Projection Surface Reconstruction

计量

出版历程

目录

作者简介:
宁楠楠哈尔滨理工大学自动化学院硕士研究生. 2009 年获得齐齐哈尔大学计算机与控制工程学院学士学位. 主要研究方向为模式识别与智能系统.E-mail：ningnannan@fingerpass.net.cn

通讯作者:
刘侠哈尔滨理工大学自动化学院教授. 2006 年获得哈尔滨工程大学自动化学院博士学位. 主要研究方向为模式识别与智能系统.E-mail：liuxia@hrbust.edu.cn