基因调控网络的控制：机遇与挑战

王沛; 吕金虎

doi:10.3724/SP.J.1004.2013.01969

基因调控网络的控制：机遇与挑战

doi: 10.3724/SP.J.1004.2013.01969

王沛¹,
吕金虎²

1.
河南大学数学与信息科学学院开封 475004;
2.
中国科学院数学与系统科学研究院北京 100190

基金项目:

国家自然科学基金（61304151，61025017，11072254，11105040），河南大学校内自然科学基金（2012YBZR007）资助

详细信息

作者简介:
王沛博士，河南大学数学与信息科学学院讲师. 主要研究方向为系统生物学，复杂系统与复杂网络.E-mail：wp0307@126.com

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出版历程
- 收稿日期: 2013-09-11
- 修回日期: 2013-09-22
- 刊出日期: 2013-12-20

Control of Genetic Regulatory Networks：Opportunities and Challenges

WANG Pei¹,
LV Jin-Hu²

1.
School of Mathematics and Information Science, Henan University, Kaifeng 475004;
2.
Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190

Funds:

Supported by National Natural Science Foundation of China (61304151, 61025017, 11072254, 11105040) and Scientific Research Foundation of Henan University (2012YBZR007)

摘要

摘要: 众所周知，基因调控网络（Genetic regulatory networks，GRNs）是一类基本且重要的生物网络.基因调控网络可以通过输入、噪声、参数以及正负反馈等进行功能的鲁棒性调节与控制.本文首先简要回顾了基因调控网络控制方面的若干研究进展，然后提出了一些与控制相关的基因调控网络的基本科学问题.基因调控网络的控制以生命科学为背景，以控制理论为理论基础.过去几十年，控制论的基本思想与方法逐步渗透到基因调控网络的研究中.同时，来源于生命科学的控制问题也为我们提出了新的机遇与挑战.基因调控网络的控制对生命科学中困扰人类的基本问题，如延长寿命、治愈癌症、糖尿病等顽疾有着非常重要的现实意义.此外，基因调控网络控制研究对合成生物学、网络医学、个性化医学等相关学科的发展具有潜在的应用价值.
- 系统生物学 /
- 基因调控网络 /
- 噪声 /
- 正反馈 /
- 负反馈
Abstract: It is well known that genetic regulatory networks (GRNs) are fundamental and important biological networks. This paper briefly reviews the main research progresses in the control of GRNs. Moreover, this paper proposes some fundamental scientific problems for the control of GRNs. In fact, life sciences and control theory are the real-world background and theoretical basis for the control of GRNs, respectively. Over the last few decades, the basic idea and methods of control theory have gradually infiltrated into the research of GRNs. At the same time, some control problems from life sciences also provide new opportunities and challenges for control science. The control of GRNs guides some potential routes to resolve the long-time perplexing problems in life sciences, such as the prolonging of lifespan, curing cancer and diabetes. Furthermore, the control of GRNs has potential real-world applications for the rapid developments of synthetic biology, networked medicine and personalized medicine.
- Systems biology /
- genetic regulatory network (GRN) /
- noise /
- positive feedback /
- negative feedback

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