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摘要: 孤独症是一种先天的大脑发育障碍性疾病, 孤独症儿童的早期评估诊断尤为重要. 脑电图(Electroencephalography, EEG)是大脑神经细胞电生理活动在大脑皮层或头皮表面的总体反映. EEG信号中包含了大量的生理与疾病信息, 可为某些脑疾病提供诊断依据. 本文按照国际10-20系统标准电极分布将全脑划分为5个脑区, 采用小波相干性算法对孤独症(Autistic spectrum disorder, ASD)儿童和正常(Typical development, TD)儿童任意两通道之间在不同节律下的连接性进行计算, 按脑区进行划分, 得到脑区内和跨脑区功能连接结果, 随后应用独立样本t检验分析和FDR (False discovery rate)多重校正方法后给出脑区内和跨脑区在不同节律下的组间差异.结果表明, ASD组相对于TD组跨脑区连接和脑区内连接普遍较弱, 除delta频段外其他频段均差异显著, 尤其是额叶与其他脑区连接. 多重校正后通道间长程连接中额叶与枕叶、中央区与枕叶在四个频段差异显著较明显, 通道间短程连接额叶在theta和alpha频段较显著, 其他频段其他脑区对比不显著.Abstract: Autistic spectrum disorder (ASD) is a congenital brain development disorder, and early assessment of autistic children is particularly important. Electroencephalography (EEG) is the overall reflection of the electrophysiological activity of brain cells on the surface of the cerebral cortex or scalp. The EEG signal contains a large amount of physiological and disease information, which can provide a basis for diagnosis of certain brain diseases. In this paper, the whole brain is divided into five brain regions according to the 10-20 international standard electrode distribution, and the wavelet coherence algorithm is used to calculate its functional connections between autism (ASD) children and normal children under different rhythms. The functional connection results in the brain region and the trans-brain region according to the brain area were obtained. Then, the independent sample t-test analysis and the FDR (false discovery rate) multiple correction method were applied to analyze the difference in the inter-brain and trans-brain regions between the groups under different rhythms. The results showed that the ASD group was generally weaker than the TD (typical development) group in the trans-brain connection and the inter-brain region. The other bands except the delta band were significantly different, especially the connectivity between frontal and other brain regions. In the long-range connection between the multiple corrections, the frontal lobe and the occipital lobe, the central region and the occipital lobe were significantly more prominent in the four frequency bands. The short-range connection between the channels was significantly higher in theta and alpha bands, and the other brain regions were not significantly contrasted.
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Key words:
- Autistic spectrum disorder (ASD) /
- electroencephalography (EEG) /
- wavelet coherence /
- functional connectivity
1) 本文责任编委 张道强 -
图 1 正常儿童与孤独症儿童小波相干值对比图
Fig. 1 Comparison of wavelet coherence values between normal children and autistic children
图 2 正常儿童与孤独症儿童脑区小波相干值统计检验结果图
Fig. 2 Statistical test results of wavelet coherence values between normal children and autistic children
图 3 孤独症组与正常组脑区内通道间小波相干值显著性比较图
Fig. 3 Statistical test results of wavelet coherence values between normal children and autistic children
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