Prediction of Malignant and Benign Lung Tumors Using a Quantitative Radiomic Method
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摘要: 肺癌是世界范围内致死率最高的癌症之一，肺肿瘤的良恶性诊断对于治疗方式选择意义重大.本文借助影像组学（Radiomics）方法利用LIDC（Lung imaging database consortium）肺癌公开数据库中619例病人的肺癌计算机断层（Computed tomography，CT）影像数据，分割出病变区域，并结合肿瘤医学特性和临床认知，提取反映肿瘤形状大小、强度和纹理特性的60个定量影像特征，然后利用支持向量机（Support vector machine，SVM）构建诊断肺肿瘤良恶性的预测模型，筛选出对诊断肺肿瘤良恶性有价值的20个影像组学特征.为肺肿瘤良恶性预测提供了一种非入侵的检测手段.随着CT影像在肺癌临床诊断中的广泛使用，应用样本量的不断增加，本文方法有望成为一种辅助诊断工具，有效提高临床肺肿瘤良恶性诊断准确率.Abstract: Lung cancer is a leading cause of cancer mortality around the world. Accurate diagnosis of lung cancer is significant for treatment regimen selection. Radiomics refers to comprehensively quantifying the tumor phenotypes by applying a large number of quantitative image features. Here we analyze a computed tomography (CT) data set of 619 patients with lung cancer on the lung image database consortium (LIDC) by radiomic method. Combining with the medical character and clinical recognition of lung tumor, we present a radiomic analysis of 60 features. Then, we use SVM to build a prediction model and find radiomic features which have predictive value for discrimination of malignant and benign lung tumors. Nowadays, as CT imaging is routinely used in lung cancer clinical diagnosis, there is an increase in data set size. We consider that our radiomic prediction model will be developed a valuable medical software and an auxiliary tool which can provide malignant and benign information of lung tumors efficiently.
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Key words:
- Radiomics /
- lung cancer /
- image segmentation /
- feature extraction /
- support vector machine (SVM)
1) 本文责任编委 朱朝喆 -
图 2 肺肿瘤良恶性预测模型的生成和验证示意图
Fig. 2 Diagram of generation and validation of benign and malignant discrimination model of lung tumor
表 1 肺肿瘤良恶性预测模型的诊断准确率
Table 1 Diagnostic accuracy of benign and malignant discrimination model of lung tumor
数据集 灵敏度(%) 特异性(%) 阳性预测值(%) 阴性预测值(%) 准确度(%) 训练集 82.2 82.6 82.5 82.2 82.4 (175/213) (176/213) (175/212) (176/214) (351/426) 测试集 75.4 81.6 87.6 65.9 77.7 (92/122) (58/71) (92/105) (58/88) (150/193) 总计 79.9 82.4 84.2 77.5 80.9 (257/335) (234/284) (267/317) (234/302) (501/619) 
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