Abstract: This paper introduces the application of an industrial control minicomputer in the process of refrigeration technology in a cold storage with a capacity of ten thousand ton level. The selection of scheme, the design of system, the measure of reliability and its operating situation are briefly described. Owing to the great inertia of the refrigeration system, minicomputer Js-10B with simpler functions and cheaper price is used for the real-time process control so as to put the specifications of the simpler minicomputer into comparatively full play. Through the combination of the measures on the hardware and the software, the reliability and the ability of anti-interference have been enhanced.