Abstract: By combining self-tuning controller with Smith-predictor, a multivariable pole assignment self-tuning Smith controller is proposed for industrial processes with long time delay. The proposed controller not only can predict the process output and adapt to the control of non-minimum phase system but also has an asymptotic servo property. Its structure is simple. The algorithm has been used to control a group of cover annealing furnaces with microcomputer in an iron and steel company. The control accuracy and temperature distribution nonuni-fortuity in the annealing furnace are within ±3°C.